Role of Omega-3 Fatty Acids on Lipid
Profile in Diabetic Dyslipidaemia: Single
Blind, Randomised Clinical Trial
Published: March 1, 2017 | DOI: https://doi.org/10.7860/JCDR/2017/20628.9449
Shaylika Chauhan, Hanish Kodali, Jawad Noor, Karuna Ramteke, Vidisha Gawai
1. Resident Physician, Department of Internal Medicine, Saint Peter’s University Hospital, New Brunswick, New Jersey, USA.
2. Epidemiology-Biostatistics, MPH, City University of New York, New York, USA.
3. Research Associate, Department of Pulmonology, New York Methodist Hospital, New York, USA.
4. Medical Advisor Gufic Biosciences, Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India.
5. Medical Officer, Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India.
Correspondence
Dr. Shaylika Chauhan,
Resident Physician, Department of Internal Medicine, Saint Peter’s University Hospital, New Brunswick, New Jersey, USA.
E-mail: schauhan@saintpetersuh.com
Introduction: Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipaemia, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular complications. Omega-3 fatty acids are fish oil derivative introduced in the market for dyslipidaemia associated with increased triglyceride level.
Aim: To study the effect of omega-3 fatty acids on lipid profile in Type II diabetes patients.
Materials and Methods: This study was prospective, single blind, randomized comparative trial. Hundred patients were randomized into three groups. Group I received metformin 500 mg twice daily and placebo, Group II received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) once daily and the Group III received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) twice daily. ANOVA test was applied for analysis.
Results: Group II was effective in reducing the triglyceride level from 144.59±14.18 mg/dl to 101±13.31 mg/dl which was significant as compared to Group I from 147.67±18.57 mg/dl to 145.8±19.86 mg/dl respectively. Group III containing 1 g of omega-3 fatty acids twice daily showed decrease from 144.83±22.17 mg/dl to 86±17.46 mg/dl and was more effective in reducing triglyceride levels than Group II containing 1 gram of omega-3 fatty acids once daily.
Conclusion: Omega-3 fatty acids can be given in conjunction with metformin to reduce triglyceride levels in diabetic dyslipidaemia without any adverse drug reactions or any drug interaction. Omega-3 fatty acids were effective in reducing the triglyceride level significantly as compared to placebo. Two grams of omega-3 fatty acids were more effective than 1 gram of omega-3 fatty acids in reducing triglyceride levels.
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